Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 Nov 15;8:1527. doi: 10.1038/s41467-017-01657-3

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 5 — Literature, vendor, and cheminformatics analyses of reported HAT inhibitors show concerning trends. a Many HAT inhibitors are highly prevalent in the scientific literature. Shown are the number of reviews (blue subset), non-reviews (red subset), and total unique citations (red plus blue subsets) cataloged in the SciFinder® database for the original reports of compounds 1–23 as HAT inhibitors. Data accessed 03 June 2017. b Most HAT inhibitors are widely commercially available. Shown are the number of vendors listing compounds 1–23 for purchase according to the SciFinder® database, either in-stock or synthesis-on-demand. Data accessed 03 June 2017. c Analysis of original publications for compounds 1–23 shows common experiments for compound selectivity, mechanism of action, assay interference, target engagement, and purity/identity are not routinely performed. d Many of the reported HAT inhibitors tested have poor calculated physicochemical properties (logP, APT)