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. 2017 Nov 15;7:15678. doi: 10.1038/s41598-017-15901-9

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Chronic UV-exposure results in lamin B1 reduction in mouse skin. (a) Experimental set-up. (b) H&E staining of UV-exposed versus control skin. (c) Quantification of epidermal thickness (n = 5). (d) Immunofluorescence analysis of lamin B1 and lamin A/C expression (LMNB1; green, LMNA/C; red). Bars, 20 µm. (e) Quantification of LMNB1 and LMNA/C levels throughout the epidermis, normalized to non-irradiated controls. n = 3, ***P < 0.001. (f) Immunofluorescence analysis of lamin B1 expression (LMNB1; green, P-cadherin; red). Bars, 20 µm. (g) Quantification of LMNB1 in basal and suprabasal layers, normalized to LMNB1 intensity of non-irradiated basal cells; n = 5, all graphs show mean ± SD, ****P < 0.0001).

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