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. 2017 Nov 15;7:15678. doi: 10.1038/s41598-017-15901-9

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Restoration of lamin B1 levels upon skin regeneration. (a) Experimental set-up. (b) H&E staining of skin post-irradiation (D0) and after recovery (D24). (c) Quantification of epidermal thickness (n = 7). (d) Immunofluorescence analysis of LMNB1 (green) and LMNA/C (red) expression in D0 versus D24 skin. Bars, 20 µm. (e) Quantification of LMNB1 and LMNA/C at D0 versus D24; normalized to intensity of D0; n = 3; ***P < 0.001. (f) Immunofluorescence analysis of LMNB1 (green) and P-cadherin (red) expression in D0 versus D24 skin. Bars, 20 µm. (g) Quantification of LMNB1 in basal and suprabasal layers D0 versus D24; normalized to LMNB1 intensity of D0 basal cells; n = 7; all graphs show mean ± SD, ***P < 0.001, n.s.; non-significant.

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