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. 2017 Nov 15;7:15614. doi: 10.1038/s41598-017-15057-6

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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ATG3-promoted vesicle aggregation. (A) Time-course of 3 mM LUV (PC:DOPE:CL 60:30:10 mol ratio) aggregation induced by 10 μM ATG3. Arrow indicates addition of ATG3. Each curve represents the mean ± SE (n = 3). Note that data for ATG3, for LUV only and for ATG3 K9D/K11D + LUV overlap. (B) Effect of lipid composition and ATG3 concentration on LUV aggregation. Bars represent mean ± SE (n = 3) of ΔA400. ***P ≤ 0.001, **P ≤ 0.01, *P ≤ 0.05 of unpaired t-test. (C) Representative images of ATG3-induced aggregation of LUV of different lipid compositions: PC:DOPE (70:30 mol ratio), PC:DOPE:CL (60:30:10 mol ratio) or PC:DOPE:PA (50:30:20 mol ratio). Scale bars: 30 μm.