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. 2017 Nov 15;7:15599. doi: 10.1038/s41598-017-15876-7

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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ARTO accelerates skin contraction and wound healing. (a) The structure of ARTO. (b,c) Representative photographs of wound healing in CTRL and ARTO-treated mice at various time points after wounding. The wound closure results were quantified on days 3, 7, and 15 after wounding. (d,e) H&E-stained sections on days 1, 3, 7, and 15 after wounding. The widths of the wound areas are marked by arrows and were quantified on days 1, 3, 7, and 15 after wounding. (f) Immunohistochemistry was performed to identify α-SMA in wounds on days 3, 7, and 15 after wounding. (g) The α-SMA levels were determined by western blot analysis. The data are shown as the means ± S.D. N = 6–18 wounds/group and *P < 0.05.