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. 2017 Nov 15;7:15599. doi: 10.1038/s41598-017-15876-7

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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ARTO enhances collagen deposition and maturation. The wounded sections stained with Mallory’s trichrome (a) and picrosirius red (b) showed that more newly formed and mature collagen fibers were observed in ARTO-treated wounds. The widths of the wound areas are marked by arrows. (c) TEM images of connective tissue on day 15 after wounding. Higher magnification images (lower panel) illustrate different collagen fibril diameters, amounts, and arrangements in skin wounds. (d) Western blot analysis of the skin showed collagen deposition (collagen type I and III) on days 7 and 15 after wounding. (e) TGF-β level was analyzed in GM05386 fibroblasts and skin by ELISA and western blot. (f) The collagen I and α-SMA levels were determined by western blot analysis. The data are shown as the means ± S.D. N = 3–6 wounds/group and *P < 0.05.