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. 2017 Jul 25;40(12):1219–1229. doi: 10.1007/s40264-017-0574-6

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© The Author(s) 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 3 — Temporal relationship between human papillomavirus (HPV) vaccination and the development of symptoms in patients diagnosed as having HPV vaccine-related symptoms. The period ranges from May 2010 to December 2016. a Number of patients who received the first injection of HPV vaccine each month. The peak period seems to be between July 2011 and September 2012. An arrow indicates the time when the Japanese Ministry of Public Health, Labour and Welfare stopped recommending HPV vaccination. b Number of patients who developed symptoms each month. The peak period appears to be between September 2011 and August 2013