Table 2.
Unadjusted and adjusted OR of prior conditions for patients prescribed any paracetamol versus ibuprofen alone and paracetamol only versus ibuprofen only (N = 144,337)
| Condition | Any paracetamola [% (N)] | Ibuprofen [% (N)] | Unadjusted OR (95% CI) | Adjusted ORb (95% CI) |
|---|---|---|---|---|
| GI bleed | 3.1 (2372) | 2.2 (1480) | 1.5 (1.4–1.6) | 1.4 (1.3–1.5) |
| MI | 1.6 (1175) | 0.4 (288) | 3.7 (3.3–4.2) | 2.6 (2.3–3.0) |
| Renal disease | 7.4 (5643) | 2.8 (1887) | 2.8 (2.7–3.0) | 1.8 (1.7–1.9) |
| Stroke | 2.5 (1874) | 0.7 (494) | 3.5 (3.2–3.8) | 2.1 (1.9–2.3) |
| Paracetamol only | Ibuprofen only | Unadjusted OR (95% CI) | Adjusted ORb (95% CI) | |
|---|---|---|---|---|
| GI bleed | 3.3 (2201) | 2.2 (1480) | 1.5 (1.4–1.6) | 1.5 (1.4–1.6) |
| MI | 1.7 (1149) | 0.4 (288) | 4.1 (3.6–4.7) | 2.9 (2.5–3.3) |
| Renal disease | 8.0 (5382) | 2.8 (1887) | 3.1 (2.9–3.2) | 1.9 (1.8–2.1) |
| Stroke | 2.7 (1791) | 0.7 (494) | 3.8 (3.4–4.2) | 2.3 (2.0–2.5) |
OR odds ratio, CI confidence interval, GI gastrointestinal, MI myocardial infarction
aAny paracetamol includes patients who received both paracetamol and ibuprofen on the index date
bAdjusted by age group and sex