. 2017 May 5;65(6):501–520. doi: 10.1007/s00005-017-0469-3

Table 2.

Phenotypes of regulatory B cell subsets of mouse (A) and human (B)

Regulatory B cell (mouse)	Phenotype	Mechanism of suppression	References
(A)
B10 cells	CD19^hiCD1d^hiCD5⁺	IL-10	Yanaba et al. (2008, 2009)
B-1a cells	CD19⁺CD5⁺	IL-10	O’Garra et al. (1992)
MZ B cells	CD19⁺CD21^hiCD23⁻CD24^hiIgM^hiIgD^loCD1d^hi	IL-10	Gray et al. (2007a, b)
T2-MZP B cells	CD19⁺CD21^hiCD23^hiCD24^hiIgM^hi IgD^hiCD1d^hi	IL-10	Evans et al. (2007)
GIFT-15 B cells	B220⁺CD21⁺CD22⁺CD23⁺CD24⁺ CD1d⁺CD138⁺IgD⁺IgM⁺	IL-10	Rafei et al. (2009)
Plasmablasts	CD138⁺CD44^hi	IL-10	Matsumoto et al. (2014)
TIM-1 B cells	TIM-1⁺	IL-10	Ding et al. (2011)
Plasma cells	CD138^hiIgM⁺TACI⁺CXCR4⁺ CD1d^hiTim1^int	IL-10, IL-35	Neves et al. (2010) Shen et al. (2014)
PD-L1^hi B cells	CD19⁺PD-L1^hi	PD-L1	Khan et al. (2015)
Killer B cells	CD5⁺CD178⁺	FasL	Lundy and Fox (2009)
CD73⁺ B cells	B220⁺CD39⁺CD73⁺	Adenosine	Kaku et al. (2014)

Regulatory B cell (human)	Phenotype	Mechanism of suppression	References
(B)
B10 cells	CD19⁺CD24^hiCD27⁺	IL-10	Iwata et al. (2011)
Immature B cells	CD19⁺CD24^hiCD38^hi	IL-10, PD-L1	Blair et al. (2010)
Br1 cells	CD25^hiCD71^hiCD73^lo	IL-10, IgG4	van de Veen et al. (2013)
Plasmablasts	CD27^intCD38^hi	IL-10	Matsumoto et al. (2014)
iBregs	–	TGF-β, IDO	Nouel et al. (2015)
GrB⁺ B cells	CD19⁺CD38⁺CD1d⁺IgM⁺CD147⁺	GrB, IL-10, IDO	Lindner et al. (2013)
CD73⁺ B cells	CD39⁺CD73⁺	Adenosine	Saze et al. (2013)

A large variety of regulatory B cells have been identified. The majority of them are characterized by the production of IL-10, and the most investigated are B10 B cells detected in mice and humans

iBregs inducible regulatory B cells