Table II.

Summary of reported analyses of heart failure clinical trial databases for gender related differences in survival.

Study	Year	Total Patients	%F	F/U Yrs.	Overall Survival	CV	HF	ICM	DCM	Population	Hormone Status	ref #
First Database	1999	471	23.8	1.5	F>M		F>M	NS	F>M	end-stage HF	none	1
New Idiopathic Cardiomyopathy	2000	1230	40	4.4	F>M				F>M	New DCM only	none	2
Charm Database	2007	7599	31.6	3.2	F>M		F>M	F>M	F>M	Systolic & Diastolic HF	No difference HRT vs. No HRT	3
5 Pooled Trials	2007	11642	24.5	0.6–2.5	F>M		F>M	F>M	F>M	systolic HF	none	4
Cleveland Clinic Scar & Survival	2009	339	24	4	M>F		M>F	M>F	NA	established CAD/MI only	none	5
CV Health Study Database	2009	1264	51	3			F>M	F>M	ND	65 or over Diastolic & systolic HF 80% dead by 3 yrs	none	6
Digitalis Trial Group Database	2009	3338	50	3.2	F>M	F>M	ND			HF	none	7
HF Clinic Database	2011	531	26	1	F>M		ND			outpatient, systolic & valve disease	none	8

HF -heart failure; F -female; M -male; ND -not done; NA -Not applicable; DCM -dilated cardiomyopathy (not ischemic); ICM -ischemic cardiomyopathy; column on far right, numbers correlate with following references: 1. Adams et al., 1999; 2. Kong et al., 2004; 3. O’Meara et al., 2007; 4. Frazier et al., 2007; 5. Kwon, Halley, & Popovic, 2009; 6. Parashar et al., 2009; 7. Ahmed et al., 2011; 8. Feldman et al., 2011.