Table IV.

Summary of ER knockout mice.

Gene	Knockout	Mutation	Company	Original Paper	Names	Used by Review References
esr1	ERα	disruption, exon 2		Lubhan, 1993	Chapel Hill (CH), αERKO	1, 2, 3, 4
esr1	ERα	disruption, exon 2	Taconic (discontinued)	Lubhan, 1993		5
esr1	ERα	disruption, exon 2	Jackson Labs	Lubhan, 1993
esr1	ERα	deletion, exon 3		Dupont, 2000	Strasbourg (ST), ERαKO, Ex3αERKO	6
esr2	ERβ	disruption,		Krege, 1998	Chapel Hill,	2, 3, 7, 8
		exon 3			ERβKOCH, βERKO
esr2	ERβ	disruption, exon 3	Taconic (discontinued)	Krege, 1998		5, 9, 10
esr2	ERβ	disruption, exon 3	Jackson Labs	Krege, 1998
esr2	ERβ	disruption, exon 3		Krege, 1998	Transfer to Karolinska Institute, ERβKOKI
esr2	ERβ	disruption, exon 3		Dupont, 2000	Strasbourg, ERβKOST	6
esr2	ERβ	Translational block, post-codon 19		Shughrue, 2002	Wyeth, ERβKOWY
esr2	ERβ	deletion, exon 3		Antal, 2008	ERβSTL-/L-
esr1+esr2	ERα+ERβ	cross α, β KOCH		Couse, 1999	Chapel Hill	11, 12
esr1+esr2	ERα+ERβ	cross α, β KOST		Dupont, 2000	Strasbourg
esr1+esr2	ERα+ERβ	cross αKOCH, βKOWY		Shughrue, 2002	Wyeth

Column on far right, numbers correlate with following references, which used the respective mouse models: 1. Couse, J., Curtis, S., et al. 1995. 2. Babiker, F., Lips, D. et al. 2006. 3. Pedram, A., Razandi, M. et al. 2008. 4. Zhai, P., Eurell, T. et al. 2000. 5. Jesmin, S., Mowa C., et al. 2010. 6. Darblade, B., Pendaries, C. et al. 2002. 7. Pelzer, T., Arias Loza, P., et al. 2005. 8. Pedram, A., Razandi, M. et al. 2010. 9. Wang, M., Wang, Y. et al. 2009. 10. Fliegner, D., Schubert, C., et al. 2010. 11. Lindberg, M., Moverare, S., et al. 2003. 12. Karas, R., Schulten, H., et al. 2001.