Figure 6.
Detection of RPE-Specific Antibody in iPSC-RPE Cell Transplanted Animal Models
The sera from several operated monkeys (all 12 weeks after surgery) were collected, and transplanted iPS-RPE cells were prepared. After RPE cell fixation, immunohistochemistry was performed for RSA detection using the diluted sera. Nuclei were counterstained with DAPI.
(A–D) 46a RPE cells + serum from a TLHM1 monkey, (B) 46a RPE cells + serum from a TLHM15 monkey that received injection into the eye, (C) 1121A1 RPE cells + serum from an S3-2 monkey, and (D) 46a RPE cells + serum from a normal K-151 monkey. Scale bars, 200 μm.