Table 1.

Upregulated and Downregulated miRNAs in Differentiated Cells Compared with Undifferentiated Cells

Endoderm			Mesoderm
miRNA	Fold Change of Expression		miRNA	Fold Change of Expression
	Compared with ESCs	Compared with ME		Compared with ESCs	Compared with DE
Upregulated			Upregulated
miR-1263	n.d. in ESC	n.d. in ME	miR-196b-5p	n.d. in ESC	n.d. in DE
miR-1243	1354.3	2.1	miR-483-3p	n.d. in ESC	n.d. in DE
miR-375	988.6	102.8	miR-675-5p	n.d. in ESC	n.d. in DE
miR-888-5p	74.6	9.7	miR-214-3p	1387.6	n.d. in DE
miR-489-3p	44.4	101.2	miR-10a-5p	563.9	2043.6
miR-371-3p	33.9	20.2	miR-199a-3p	281.5	320.2
miR-7-2-3p	29.3	26.3	miR-145-5p	129.3	105.6
miR-373-3p	19.2	6.3	miR-193-5p	64.4	300.0
miR-372-3p	17.5	9.1	miR-143-3p	57.2	n.d. in DE
miR-661	13.8	12.7	miR-483-5p	46.1	45.7
miR-200a-5p	9.4	27.3	miR-532-3p	28.5	11.0
miR-1260a	2.4	10.1	miR-455-3p	28.0	11.6
			miR-365-3p	20.0	24.4
			miR-15a-5p	18.4	13.2
			miR-362-5p	16.6	12.4
Downregulated			Downregulated
miR-154-3p	n.d. in DE	n.d. in DE	miR-98-5p	n.d. in ME	n.d. in ME
miR-518e-3p	5.8 × 10−3	5.5 × 10−2	miR-367-3p	1.2 × 10−2	6.0 × 10−2
miR-187-3p	3.9 × 10−2	6.7 × 10−1	miR-302c-5p	1.2 × 10−2	1.0 × 10−2
miR-520g-3p	4.2 × 10−2	5.3 × 10−2	miR-302b-3p	2.4 × 10−2	2.7 × 10−2
miR-517a-3p	5.7 × 10−2	6.0 × 10−2	miR-302d-3p	3.0 × 10−2	3.3 × 10−2
miR-512-3p	5.8 × 10−2	9.3 × 10−2	miR-302d-5p	3.1 × 10−2	2.6 × 10−2
miR-100-5p	6.2 × 10−2	8.1 × 10−3	miR-302a-5p	3.3 × 10−2	2.3 × 10−2
			miR-200b-3p	3.9 × 10−2	3.8 × 10−2
			miR-302a-3p	5.4 × 10−2	5.6 × 10−2
			miR-31-5p	6.5 × 10−2	5.1 × 10−2
			miR-520c-3p	1.7 × 10−1	7.5 × 10−2
			miR-559	3.0 × 10−1	2.9 × 10−2
			miR-200a-5p	3.4 × 10−1	3.7 × 10−2
			miR-489-3p	4.4 × 10−1	1.0 × 10−2

n.d., not detected; DE, definitive endoderm; ME, mesoderm.