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Definition and the histological grading system for acute GI GVHD.
| Grade | Histological feature |
|---|---|
| I | Single-cell necrosis (apoptosis) noted on medium power |
| II | Evidence of epithelial damage by crypt/grandular abscesses, epithelial flattening, or glandular/crypt dilation |
| III | Dropout of one or more crypts/grands |
| IV | Total epithelial denudation |
