Figure 1.

Experimental schedule and anatomical ROI for small volume correction. (a) For each subject, we assessed resting state MRI, followed by the assessment of 2ptD thresholds of the index fingers of both the left and right hands. After baseline assessments, subjects filled out questionnaires concerning personality traits to ensure that all subjects fell within the normal range of depression and trait anxiety levels (Qsts). During the subsequent rSS intervention, one hand received 45 min of intermittent high-frequency stimulation, whereas the other hand served as a control condition. The time between the end of rSS and the start of the second RS session ranged between 35 and 70 min (50.0 ± 1.98 min). (b) Representative slices of anatomical a priori (i.e., previously deduced) regions-of-interest used for the small volume correction of statistical results. We focused on brain regions known to participate in the processing of somatosensory stimulation.