Table 1.
Heartworm isolate details for nine different heartworm (D. immitis) isolates used to assess the preventive efficacy of 3 μg/kg of oral moxidectin in dogs
| D. immitis isolate | Year isolated | Isolate location | Responsible for original isolate collection/currently maintained | Comments |
|---|---|---|---|---|
| MP3 | 2006 | GA (Northeast) | TRS Labs/Zoetis | Refractory, not resistant, published results for other products at use dose <100% [7–10]; original isolate from TRS Labs |
| Michigan | 2007 | MI | TRS Labs/Zoetis | Confirmed susceptible isolate >6 years previous from TRS Labs |
| JYD-34 | 2010 | Pittsville, IL (CHK- Kennel) | TRS Labs/Zoetis | Confirmed ML-resistant isolate from published reports [3, 4]; original isolate from TRS Labs |
| ZoeMO | 2012 | Pittsville, IL (CHK- Kennel) | Zoetis/Zoetis | Related to JYD-34, isolated from the same dog as JYD-34 but 2.5 years later. Dog had been kept in mosquito-proof quarters and received no ML preventive or adulticide therapy |
| ZoeKY | 2013 | Slayersville, KY (CHK-Kennel) | Zoetis/Zoetis | New isolate; no documented previous medical history |
| ZoeLA | 2013 | Zachary, AL (Dr. Lynn Buzhardt) | Zoetis/Zoetis | New isolate from 6-year-old English bulldog, originally from Ellis, AR, moved to Slaughter, LA, at 3 months of age; on Heartgard® for 2 years but no HW prevention for previous 3 years before isolate collection |
| GCFL | 2014 | Fort Myers, FL (Gulf Coast Human Society) | Zoetis/Zoetis | New isolate from 3-year-old heartworm-positive pit-bull mix from local humane society; no documented previous medical history |
| AMAL | 2014 | Westover, AL (Dr. Jay Crisman) | Zoetis/Zoetis | New isolate from a 3-year-old, heartworm-positive Husky with no previous documented medical history |
| ZoeAL | 2015 | Wetumpka, AL (Dr. Jay Crisman) | Zoetis/Zoetis | New isolate from a heartworm-positive 4-year-old pug with no previous ML preventive use |