Table 1. Characteristics of the Starting Compound (Boc-NH-PEG5000-OH), Intermediate Products ((Boc-NH-PEG5000)2-ABCPA and (NH2-PEG5000)2-ABCPA)), and Final PEG Macroinitiator ((Br-C(CH3)2-CO-NH-PEG5000)2-ABCPA)a.
| product | yield (%) | Mn (kDa) | PDI | free amines (%) |
|---|---|---|---|---|
| Boc-NH-PEG5000 | 5.5 | 1.05 | 0 | |
| (Boc-NH-PEG5000)2-ABCPA | 95 | 11.8 | 1.05 | 0 |
| (NH2-PEG5000)2-ABCPA | 95 | 11.8 | 1.05 | 97 |
| (Br-C(CH3)2-CO-NH-PEG5000)2-ABCPA | 80 | 12.2 | 1.07 | 5 |
a
The molecular weight (Mn) and the polydispersity index (PDI) were determined with GPC. The amount of free amines was determined with a TNBSA assay.