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Pax6, Neurog2, and Dmrt5 require Lhx2 for normal expression in the embryonic hippocampus. A, B, EmxCre; Lhx2lox/lox brains at E15 display shrunken hippocampal primordia that express Zbtb20 and Prox1 (arrowheads), indicating that the hippocampus is specified. Pax6, Neurog2, and Dmrt5, normally expressed in the hippocampal ventricular zone (B, white asterisks), are greatly reduced upon loss of Lhx2 (A, black asterisks). Scale bar, 200 μm.
