Table 3.
Protein colocalization in WT and KI Synapses
| Protein markers | Pearson R > 0.1 (%) |
||
|---|---|---|---|
| WT | KI | χ2 | |
| SERT and Talin | 83 | 49 | χ2, df = 25.76, 1 |
| z = 5.075, p < 0.0001 | |||
| SERT and pFAK | 88 | 74 | χ2, df = 6.368, 1 |
| z = 2.523, p = 0.0116 | |||
| pFAK and Synaptophysin | 76 | 88 | χ2, df = 4.878, 1 |
| z = 2.209, p = 0.0272 | |||
Significant genotype differences in the number of synapses are indicated in italics. Structured illumination microscopy of WT and KI midbrain slices was used to quantify the colocalization of the listed proteins within SERT-positive synapses. The χ2 test was used to compare the proportion of synapses with a Pearson score >0.1 to the total number of synapses (shown here as percentages) between genotypes.