Table 4.
Baseline prevalence of comorbidities in CREDIT and other large registries
| Registry | CORRONA [17, 25–27] | NOAR [17, 28] | ERAS/ERAN [14, 29] | SRR [17, 30, 31] | IORRA [17, 32, 33] | KORONA [34, 35] | CREDIT |
|---|---|---|---|---|---|---|---|
| Country | USA | UK | UK | Sweden | Japan | Korea | China |
| Number of patients | 24,989 | 1564 | 1465/1236 | 18,527 | 11,907 | 4721 | 13,210 |
| Female, % | 76.0 | 69.9 | 66.4/67.9 | 70.3 | 82.2 | 85.2 | 80.6 |
| Age, y | 58.9 ± 13.4 | 55.9 ± 14.6 | 55.3 ± 14.6/57.0 ± 14.2 | 58.0b | 55.7 ± 13.5 | 54.3 ± 12.2 | 52.9 ± 13.1 |
| Age ≥ 60, % | 47.3 | 50.9 | NR | 54.1 | 41.0 | NR | 32.7 |
| Disease duration, y | 10.1 ± 9.8 | 6.5 (median) | 0.5 (median) | NR | 8.1 ± 8.6 | 8.3 ± 7.6 | 6.8 ± 7.6 |
| CAD, % | 6.4 | 2.6 | 4.5 (ERAS) | 7.9 | 1.5 | NRc | 1.5 |
| Stroke, % | 2.1 | 2.7 | 1.5 | 3.0 | 0.3 | NRc | 0.8 |
| Prior fracture, %a | 21.6d | NR | 0.8 (ERAS) | NR | 23.7 | 16.7e | 1.7 |
| Malignancy, % | 6.8 | 8.3 | 3.0 | 12.4 | 1.1 | NR | 0.6 |
NR not reported, CAD coronary artery disease, CORRONA Consortium of Rheumatology Researchers of North America Registry, ERAS Early Rheumatoid Arthritis Study, ERAN Early Rheumatoid Arthritis Network, SRR Swedish Rheumatology Quality of Care Register, NOAR Norfolk Arthritis Register, IORRA Institute of Rheumatology Rheumatoid Arthritis Cohort, KORONA KORean Observational study Network for Arthritis, CREDIT Chinese Registry of rheumatoid arthritis
aOnly fragility fractures were collected in CREDIT, and all types of prior fractures in other cohorts bData from 12,656 patients, and standard deviation was not reported
cThe prevalence of cardiovascular disease was 4.0%, but no data on CAD or stroke separately
dData derived from 6143 RA patients with ≥1 year follow-up
eData from 3557 patients with ≥1 year follow-up