Table 1.
Demographic characteristics and the selected laboratory values for 151 patients with RA
| Stable RA | Mild RA | Moderate RA | Severe RA | RA | Control | |
|---|---|---|---|---|---|---|
| 33 patients | 32 patients | 35 patients | 51 patients | 151 patients | 43 patients | |
| Agea | 48.23 ± 10.28 | 44.12 ± 12.01 | 45.18 ± 11.01 | 49.14 ± 12.51 | 47.82 ± 13.15 | 40.28 ± 19.12 |
| Sex (male/female) | 5/28 | 4/28 | 4/30 | 3/49 | 16/135 | 20/23 |
| Disease duration [20]b | 6 (3 ~ 10) | 5 (2 ~ 10) | 3 (0 ~ 5) | 10 (1 ~ 11)** | 7(1 ~ 11) | |
| Number of joints with tendernessb | 1 (0 ~ 10) | 2 (0 ~ 10) | 3 (0 ~ 9) | 8 (6 ~ 14)*** | 5(2 ~ 13) | |
| Number of joints with swellingb | 0 (0 ~ 4) | 1 (0 ~ 4) | 3 (0 ~ 4)** | 3 (0 ~ 7) | 2 (0 ~ 6) | |
| DAS28b | 2.13 (1.83 ~ 2.32) | 2.98 (2.81 ~ 3.04)** | 4.12 (3.61 ~ 4.58)** | 6.21 (5.44 ~ 6.71)*** | 3.82 (2.81 ~ 5.635) | |
| ESRb | 18.04 (10.21 ~ 40.27) | 27.05 (14.25 ~ 45.75)** | 39.10 (23.21 ~ 51.52)** | 45.22 (33.53 ~ 58.51)*** | 37.00 (21.50 ~ 52.00) | |
| HAQb | 5.05 (2.21 ~ 10.32) | 7.04 (4.25 ~ 19.98)** | 12.05 (6.03 ~ 19.50)** | 20.03 (12.04 ~ 27.12)*** | 12.04 (5.40 ~ 20.12) | |
| Anti-CCPb | 185.04 (33.20 ~ 678.41) | 209.90 (81.62 ~ 957.71) | 195.71 (38.27 ~ 178.12) | 192.70 (16.48 ~ 294.12) | 108.7 (34.7 ~ 607.3) | |
| US7b | 0.8 (0.3 ~ 2.4) | 2.2 (0.8 ~ 5.5) | 3.2 (0.9 ~ 6.2) | 7.8 (2.6 ~ 11.2) *** | 4.0 (0.5 ~ 9.7) | |
| MMP3b | 33.40 (22.60 ~ 678.42) | 54.25 (33.23 ~ 81.60) | 105.10 (61.70 ~ 172.71)****** | 363.11 (161.52 ~ 475.92)****** | 99.3 (23.65 ~ 415.83) *** | 35.20 (25.90 ~ 48.90) |
RA rheumatoid arthritis, CCP cyclic citrullinated peptide, CRP C-reactive protein, DAS28 disease activity score in 28 joints, ESR erythrocyte sedimentation rate, HAQ health assessment questionnaire, MMP-3 matrix metalloproteinase-3, US7 the 7-joint ultrasound score
aThe data are presented as the mean ± standard deviation.
bThe data are presented as the median and interquartile range
Compared with patients with stable RA, ***p < 0.001, **p < 0.01, *p < 0.05; compared with the healthy controls, *** p < 0.001, ** p < 0.01 and * p < 0.05.