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. 2017 Nov 15;12:33. doi: 10.1186/s13020-017-0154-9

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© The Author(s) 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 5 — Inhibitory effects of HS7 on the AKT-mTOR signaling pathway and its downstream effectors in CL1-0 lung cancer cells after 72 h of treatment. a HS7 decreased the protein levels of phosphorylated AKT (p-AKT) and phosphorylated mTOR (p-mTOR) in a dose-dependent manner. b HS7 dose-dependently decreased the phosphorylated p70S6K protein (p-p70S6K). c HS7 dose-dependently decreased the HIF-1α protein. Cell lysates were analyzed by Western blot, using tubulin as loading control