Table 3

		Cardiovascular endpoints
Methylxanthine	Dose	Pericardial edema	Decreased blood flow	Absent blood flow	Thrombosis	Hemorrhage
Aminophylline	LC	2%	1%	1%	0	0
	HC	14%	16%	6%	0	2%
Caffeine	LC	0.01%	0.01%	0	0	0
	HC	12%	6.5%	9.8%	0	5.4%
Diprophylline	LC	0.01%	0.01%	0.01%	0	0
	HC	7.8%	4.95%	2.94%	0	0.01%
Doxofylline	LC	4%	4%	12%	0	0
	HC	13.7%	8.21%	11%	0	0
Etofylline	LC	0.8%	3%	2.5%	0	0
	HC	10.2%	5.6%	7.8%	0	0
IBMX	LC	3.8%	0	0.03%	0	0
	HC	18%	12.5%	15.3%	0	0.01%
Pentoxifylline	LC	0	0	0	0	0
	HC	8.5%	8.5%	5.7%	0	0
Theophylline	LC	0.01%	0.01%	0	0	0
	HC	17%	9.2%	13.8%	0	7.7%

Affected endpoints of cardiovascular system at 48 hpf. The table illustrate the percentage of embryos with a particular endpoint affected at the lowest and highest tested concentration

LC lowest concentration, HC highest concentration