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. 2017 Nov 15;12:20. doi: 10.1186/s13064-017-0096-z

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 5 — N-cadherin is associated with actomyosin mechanical forces in differentiating cones in the pre-column zone and with Müller glia inter-column bands in the mature mosaic. (A-A”) Flat-mount of retinal margin, immunolabeled for ZO1 (magenta) and N-Cadherin (green). (B-B”’) Higher magnification of pre-column zone (boxes in A-A”). N-Cadherin labeling surrounds round cone profiles and is concentrated in adherens junction puncta (arrows) outside photoreceptor profiles. Immature rods are outlined by ZO-1 (B’, B”, yellow dots) but are negative for N-cadherin (B”). Large round profiles represent immature UV cones (B’, white dot). (C-C”) Flat-mount of retinal margin, immunolabeled for phospho-Myosin light chain II (magenta) and pan-Cadherin (green). (D-D”) Higher magnification of pre-column zone (yellow box); strong pMyoII and pan-Cadherin staining of round profiles of differentiating cones. (E-E”) Higher magnification of mature lattice mosaic (white box); pMyoII and pan-Cadherin co-localize to puncta between cone columns (arrows). Scale bar: 10 μm (A” and C”)