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. 2017 Nov 15;5(21):e13490. doi: 10.14814/phy2.13490

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© 2017 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of The Physiological Society and the American Physiological Society

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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WPP produces strong E‐S potentiation in neurons from saline but not pilocarpine‐treated animals. (A) Upper Plot: Average normalized EPSP slope time course for CA1 pyramidal cells from pilocarpine‐treated (open red squares) and saline‐treated (filled black circles) rats. Responses are normalized to the average baseline response before WPP (hatched bar). No difference in average EPSP slope time courses after WPP were observed between groups. Lower Plot: Average input resistance normalized to baseline for the same data sets. (B) Average AP firing probability (Probability_AP) time course for CA1 pyramidal cells from pilocarpine‐treated (open red squares) and saline‐treated (filled black circles) rats. No differences in average AP firing probability time courses were observed. (C) LTP induced by WPP is similar in neurons from saline and pilocarpine (Pilo) treated rats. EPSP slopes measured 30 min after WPP were normalized to their respective baseline values before WPP. (D) E‐S plasticity as measured by P₅₀ Firing values in cells from pilocarpine‐treated rats was significantly lower than saline‐treated rats following WPP. * indicates significance P < 0.03. (E) E‐S plasticity is highly variable in CA1 cells from pilocarpine‐treated rats. Histogram showing that P₅₀ Firing values analyzed from CA1 pyramidal cells from saline‐treated rats (solid) are clustered at high P₅₀ Firing values, whereas those from pilocarpine‐treated rats (hatched) are more distributed.