Table 1.
Univariate and multivariate analysis (OR) of some histopathological features of nodular melanoma (NM) versus superficial spreading melanomas (SSMs)
| NM (N. 96) |
SSMs (N. 118) |
Univariate OR (95% CI)a |
Multivariatec
OR (95% CI)a |
|
|---|---|---|---|---|
| Thickness (mm) | ||||
| ≤ 1.00 | 9 (9.4) | 72 (61.0) | 1b | 1b |
| 1.01–2.00 | 24 (25.0) | 22 (18.6) | 8.73 (3.54–21.52) | 7.22 (2.73–19.05) |
| 2.01–4.00 | 44 (45.8) | 22 (16.6) | 16.00 (6.76–37.87) | 7.04 (2.54–19.56) |
| > 4.00 | 19 (19.8) | 2 (1.7) | 76.00 (15.14–381.51) | 51.78 (5.65–474.86) |
| χ2 1 trend: p value | p < 0.0001 | p < 0.0001 | ||
| Ulceration | ||||
| Absent | 46 (47.9) | 96 (81.4) | 1b | 1b |
| Present | 43 (44.8) | 18 (15.2) | 4.98 (2.59–9.57) | 1.56 (0.67–3.62) |
| Unknown | 7 (7.3) | 4 (3.4) | ||
| χ2 1: p value | p < 0.0001 | p = 0.3066 | ||
| Regression | ||||
| Absent | 65 (67.7) | 67 (56.8) | 1b | 1b |
| Present | 24 (25.0) | 46 (39.0) | 0.54 (0.30–0.98) | 0.55 (0.25–1.22) |
| Unknown | 7 (7.3) | 5 (4.2) | ||
| χ2 1: p value | p = 0.0428 | p = 0.1393 | ||
| Mitoses (n/mm2) | ||||
| ≤ 2 | 31 (32.3) | 86 (72.9) | 1b | 1b |
| 3–5 | 24 (25.0) | 14 (11.9) | 4.76 (2.19–10.34) | 2.62 (1.01–6.83) |
| > 5 | 35 (36.5) | 11 (9.3) | 8.83 (4.00–19.49) | 4.87 (1.77–13.40) |
| Unknown | 6 (6.2) | 7 (5.9) | ||
| χ2 1 trend: p value | p < 0.0001 | p = 0.0015 | ||
| TILd | ||||
| Absent | 29 (30.2) | 34 (28.8) | 1b | |
| Brisk | 14 (14.6) | 27 (22.9) | 0.61 (0.27–1.37) | |
| Non-Brisk | 46 (47.9) | 48 (40.7) | 1.12 (0.59–2.13) | |
| Unknown | 7 (7.3) | 9 (7.6) | ||
| χ2 1 trend: p value | p = 0.6174 | |||
aOdds Ratio and 95% confidence interval (CI)
bReference category
cModel including all significant terms in the univariate analysis
dTumor infiltrating lymphocytes