Table 2.
Univariate and multivariate analysis of recurrence (HR) of some histopathological features of patients with nodular melanoma (NM) and superficial spreading melanomas (SSMs)
| Recurrence | Univariate | Multivariatec | ||
|---|---|---|---|---|
| Yes (N. 53) | No (N. 161) | HR (95% CI)a | HR (95% CI)a | |
| Diagnosis | ||||
| SSMs | 14 (26.4) | 104 (64.6) | 1b | 1b |
| NM | 39 (73.6) | 57 (35.4) | 4.09 (2.22–7.53) | 1.62 (0.77–3.39) |
| χ2 1: p value | p < 0.0001 | p = 0.2016 | ||
| Thickness (mm) | ||||
| ≤ 1 | 7 (13.2) | 74 (46.0) | 1b | 1b |
| 1.01–2.00 | 7 (13.2) | 39 (24.2) | 2.07 (0.72–5.89) | 1.55 (0.51–4.71) |
| 2.01–4.00 | 28 (52.8) | 38 (23.6) | 5.85 (2.55–13.41) | 2.42 (0.89–6.54) |
| > 4.00 | 11 (20.8) | 10 (6.2) | 7.45 (2.89–19.22) | 3.13 (0.95–10.28) |
| χ2 1 trend: p value | p < 0.0001 | p = 0.0456 | ||
| Ulceration | ||||
| Absent | 29 (54.7) | 113 (70.2) | 1b | 1b |
| Present | 24 (45.3) | 37 (23.0) | 2.10 (1.22–3.61) | 0.74 (0.40–1.39) |
| Unknown | – | 11 (6.8) | ||
| χ2 1: p value | p = 0.0073 | p = 0.3513 | ||
| Regression | ||||
| Absent | 37 (69.8) | 95 (59.0) | 12 | |
| Present | 16 (30.2) | 54 (33.5) | 0.81 (0.45–1.45) | |
| Unknown | – | 12 (7.5) | ||
| χ2 1: p value | p = 0.4687 | |||
| Mitoses (n/mm2) | ||||
| ≤ 2 | 13 (24.5) | 104 (64.6) | 1b | 1b |
| > 2 | 37 (69.8) | 47 (29.2) | 4.75 (2.52–8.94) | 2.34 (1.11–4.97) |
| Unknown | 3 (5.7) | 10 (6.2) | ||
| χ2 1: p value | p < 0.0001 | p = 0.0263 | ||
| TILd | ||||
| Absent | 21 (39.6) | 42 (26.1) | 1b | |
| Brisk | 9 (17.0) | 32 (19.9) | 0.62 (0.29–1.36) | |
| Non-Brisk | 22 (41.5) | 72 (44.7) | 0.64 (0.35–1.16) | |
| Unknown | 1 (1.9) | 15 (9.3) | ||
| χ2 1 trend: p value | p = 0.1527 | |||
| Lymph nodes sentinel | ||||
| No suggest | 15 (28.3) | 81 (50.3) | 1b | 1b |
| Yes-negative | 16 (30.2) | 66 (41.0) | 1.14 (0.56–2.31) | 0.77 (0.35–1.69) |
| Yes-positive | 22 (41.5) | 14 (8.7) | 5.24 (2.71–10.13) | 2.60 (1.19–5.68) |
| χ2 1 trend: p value | p < 0.0001 | p = 0.0073 | ||
aHazard ratio and 95% confidence interval (CI)
bReference category
cModel including all significant terms in the univariate analysis
dTumor infiltrating lymphocytes