. Author manuscript; available in PMC: 2017 Nov 16.

Published in final edited form as: Leukemia. 2015 Dec 31;30(5):1062–1070. doi: 10.1038/leu.2015.357

Table 1. Recurrent mutations in CD28 in screened T-cell lymphoma cases.

Summary of mutations in CD28 found on targeted sequencing of PTCL cases, grouped by resultant mutated residue and diagnosis. Seven of 105 total cases (6.7%) had mutations at recurrent residues within CD28.

		Number (% of screened)		Total by diagnosis (%)
		T195	D124	Total by diagnosis (%)
AITL (n=53)^°		3 (5.7)	3 (5.7)^*	6 (11.3)
PTCL, NOS (n=40)	TBX21 (n=19)	1 (5.3)	0	1 (5.3)
	GATA3 (n=12)	0	0	0
	Unclassified (n=9)^°	0	0	0
ALCL, ALK- (n=12)		0	0	0
Total by residue		4	3	7 (6.7)

: this D124E case also has a T195P mutation at lower variant frequency; this case is only tabulated in the D124 column.

^°

: one case of AITL and one case of PTCL-Unclassified has only a histological diagnosis.