Table 2.
Means ± standard error of the mean (SEM) of percentages for cell viability and apoptosis with Annexin V/ Propidium iodide by flow cytometry in SCLC cancer cell lines after 24h incubation with drugs (representative data).
| Drug combinations | Dead % | Late Apoptotic % | Early Apoptotic % | Live % |
|---|---|---|---|---|
| Untreated cells SCLC | 2.6±1.5 | 7.7 ±1.5 | 4.3±1.4 | 86.9±3.5 |
| Carboplatin | 1.7±3 | 2±2.5 | 21±1.5 | 74.5±3 |
| Carboplatin + sildenafil + theophylline + roflumilast | 1.3±1 | 3±3 | 23±2 | 71.4±3.2 |
| Carboplatin + theophylline + sildenafil | 1.6±1 | 4±2.3 | 23±1 | 71.1±3 |
| Carboplatin + roflumilast + sildenafil |
1±0.5 | 4±2 | 21±2.5 | 75.4±2.1 |
| Cisplatin | 1.3±2 | 1±1.5 | 12±3 | 85±2 |
| Cisplatin + sildenafil theophylline + roflumilast | 1.5±1 | 7.7±1.2 | 14±2.1 | 76±2.8 |