Table 3.
Means ± standard error of the mean (SEM) of percentages for cell viability and apoptosis with Annexin V/ Propidium iodide by flow cytometry in SCLC cancer cell line after 48h incubation with drugs (representative data).
| Drug combinations | Dead % | Late Apoptotic % | Early Apoptotic % | Live % |
|---|---|---|---|---|
| Untreated cells SCLC | 1.5±1 | 3.9 ±1.3 | 4.2±1 | 90±3.2 |
| Carboplatin | 1±1.2 | 16±1.5 | 41±2 | 43±3.2 |
| Carboplatin + sildenafil + theophylline + roflumilast | 1±1 | 16±2.8 | 45±3.5 | 40±3 |
| Carboplatin + theophylline + sildenafil | 1.4±1.1 | 18±2 | 47±1.6 | 35±2.2 |
| Carboplatin + roflumilast + sildenafil |
2±0.9 | 25±4 | 41±1.1 | 33±2.8 |
| Cisplatin | 2.4±1.1 | 23.5±2.5 | 36±3 | 38±2.1 |
| Cisplatin + sildenafil theophylline + roflumilast | 1.8±1.1 | 10.5±2 | 62±2.2 | 25.4±2.9 |