Table 4.
Incidence of acute treatment-related toxicities
| PF group (N = 41) n (%) |
DP group (N = 45) n (%) |
P-value | |
|---|---|---|---|
| Leukocytopenia / Neutropenia | |||
| Grade 0 | 2 (4.9) | 2 (4.4) | 0.000 |
| Grade 1 | 5 (12.2) | 5 (11.1) | |
| Grade 2 | 26 (63.4) | 7 (15.6) | |
| Grade 3 | 8 (19.5) | 5 (11.1) | |
| Grade 4 | 0 (0.0) | 26 (57.8) | |
| Thrombocytopenia | |||
| Grade 0 | 19 (46.3) | 17 (37.8) | 0.608 |
| Grade 1 | 11 (26.8) | 14 (31.1) | |
| Grade 2 | 10 (24.4) | 7 (20.0) | |
| Grade 3 | 1 (2.4) | 3 (6.7) | |
| Grade 4 | 0 (0.0) | 2 (4.4) | |
| Anaemia | |||
| Grade 0 | 7 (17.1) | 2 (4.4) | 0.000 |
| Grade 1 | 24 (58.5) | 14 (31.1) | |
| Grade 2 | 7 (17.1) | 27 (60.0) | |
| Grade 3 | 3 (7.3) | 2 (4.4) | |
| Nausea and vomiting | |||
| Grade 0 | 3 (7.3) | 1 (2.2) | 0.217 |
| Grade 1 | 21 (51.2) | 24 (53.3) | |
| Grade 2 | 11 (26.8) | 18 (40.0) | |
| Grade 3 | 6 (14.6) | 2 (4.4) | |
| Liver enzyme elevation | |||
| Grade 0 | 32 (78.0) | 25 (55.6) | 0.028 |
| Grade 1 | 9 (22.0) | 20 (44.4) | |
| Oesophagitis | |||
| Grade 0 | 2 (4.9) | 0 (0.0) | 0.496 |
| Grade 1 | 13 (31.7) | 11 (24.4) | |
| Grade 2 | 11 (26.8) | 15 (33.3) | |
| Grade 3 | 15 (36.6) | 18 (40.0) | |
| Grade 4 | 0 (0.0) | 1 (2.2) | |
| Radiation pneumonitis | |||
| Grade 0 | 30 (73.2) | 34 (75.6) | 0.436 |
| Grade 1 | 6 (14.6) | 7 (15.6) | |
| Grade 2 | 1 (2.4) | 3 (6.7) | |
| Grade 3 | 4 (9.8) | 1 (2.2) |
Note: Acute toxicities were evaluated according to the Common Terminology Criteria for Adverse Events version 3.0 (CTCAE 3.0).