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. 2017 Oct 12;8(18):3675–3681. doi: 10.7150/jca.21148

Figure 2.

Figure 2

Cpt1c is induced under metabolic stress and down-regulation of Cpt1c promotes cancer cells death facing metabolic stress. (A): KTC-1 cells were cultured in hypoxia for 0, 1, 2 and 3 day, and Cpt1c expression was evaluated by qRT-PCR. (B): B-CPAP cells were cultured in low glucose (20, 5, 1, 0.5 and 0 mM) for 48h, and Cpt1c expression was evaluated by qRT-PCR. (C): KTC-1 cells and B-CPAP cells with Cpt1c siRNA and control were cultured in hypoxia for for 0, 1, 2 and 3 day , and cell viability was measured by CCK-8. (D) KTC-1 cells and B-CPAP cells with Cpt1c siRNA and control were cultured in low glucose (20, 5, 1, 0.5 and 0 mM) for 48h, and cell viability was measured by CCK-8. *P < 0.05, **P < 0.01 VS control.