Table 3.

Factors associated with postprogression survival stratified by mutation type

	Exon 19 deletion		L858R
	Univariate p value	Multivariate p value	Univariate p value	Multivariate p value
Age (>=65y)	0.824		0.200
Female	0.743		0.214
Non-smoker	0.673		0.310
Line of tyrosine kinase inhibitor	0.038	0.081	0.235
Slow tumor growth (stable disease)	0.300		0.876	0.007
Original site progression	0.681		0.006	<0.001
Number of extracranial lesions	0.812		0.300
Brain metastases	0.111		0.641	0.032
Immediate chemotherapy	0.476		0.559
Any definitive local therapy	0.166		0.110
Tyrosine kinase inhibitor continuation	0.013	0.023	0.733
Longer progression-free survival	0.720		0.336