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Exponential effect curves of the combination of 5-FU and curcumin in MKN45, AGS and GES-1 cells for 48 h or 72 h treatment. CI: combination index; Fa was the combination effect of two drugs. When CI > 1, antagonist effect; CI = 1, additive effect; and CI < 1, synergistic effect. Each point is corresponding to a CI value of different drug combination effects. The results are representative of at least three independent experiments run in triplicate.
