Table 3.
Univariate and multivariate analysis of disease-free survival in HCC
| Variables | Univariate analysis | Multivariate analysis | |||
|---|---|---|---|---|---|
| HR (95% CI) | P-value | HR (95% CI) | P-value | ||
| Age (≥ 50 vs. 50 years*) |
1.046 (0.527-2.075) | 0.898 | — | — | |
| Gender (female vs. male*) |
0.643 (0.154-2.688) | 0.545 | — | — | |
| HBV (positive vs. negative*) |
1.255 (0.441-3.572) | 0.670 | — | — | |
| Tumor size (≥ 5 vs. < 5 cm*) |
1.374 (0.676-2.795) | 0.380 | — | — | |
| Tumor number (multiple vs. single*) |
1.342 (0.581-3.101) | 0.492 | — | — | |
| Tumor encapsulation† | 1.144 (0.754-1.736) | 0.526 | — | — | |
| TNM stage (III + IV vs. I + II*) |
1.692 (0.846-3.384) | 0.137 | — | — | |
| Liver cirrhosis (positive vs. negative*) |
1.021 (0.502-2.076) | 0.954 | — | — | |
| Histological differentiation‡ | 1.243 (0.619-2.498) | 0.541 | — | — | |
| Serum AFP (≥ 400 vs. < 400 µg/L*) |
1.256 (0.628-2.510) | 0.519 | — | — | |
| SMOC2 (high vs. low*) | 0.334 (0.166-0.671) | 0.002* | 0.348 (0.172-0.703) | 0.003* | |
| Vascular invasion (positive vs. negative*) |
3.157 (1.292-7.712) | 0.012* | 2.842 (1.150-7.023) | 0.024* | |
| Distant metastasis (positive vs. negative*) |
1.594 (0.611-4.158) | 0.340 | — | — | |
HR, hazard ratio; CI, confidence interval; AFP, alfa fetoprotein; TNM, tumor, node, metastasis *P < 0.05 was considered statistically significant.
*, Reference group
†, Tumor encapsulation was evaluated as an ordinal categorical variable according to the completeness of the tumor (1: complete; 2: incomplete; 3: none).
‡, Histological differentiation was evaluated as an ordinal categorical variable according to the degree of tumor differentiation (1: well; 2: moderate; 3: poor).