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. 2017 Oct 17;8(18):3868–3875. doi: 10.7150/jca.21444

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The correlation between CD68+ and CD163+ macrophages during cervical carcinogenesis and carcinoma progression. (A) Significant differences in the mean macrophage counts between the subgroups with or without high-risk human papillomavirus (hr-HPV) infection (all p < 0.05). (B) Correlation of macrophages measured by CD68 or CD163 in different histological cervical lesions. The level of CD68+ macrophages showed a positive correlation with CD163+ macrophages (r = 0.808, p = 0.000, Pearson Correlation Coefficient). The line represents the calculated regression line. (C) The counts of CD68+ and CD163+ macrophages (per ×400 field) in epithelium (white bars) and stroma (black bars) in different histological cervical lesions: normal, cervical intraepithelial neoplasia (CIN) I, CIN II-III, squamous cell carcinoma (SCC). Values presented in median (25th-75th percentile).