Table 1.

Adaptations in serum and hepatic lipid profiles during mouse pregnancy

			Advanced Pregnancy
	Nonpregnant, D0	Early Pregnancy, D7	D10	D14	D18
Serum
Triglycerides, mmol/l	0.80 ± 0.04	0.76 ± 0.11	1.16 ± 0.06*	1.34 ± 0.16†	1.46 ± 0.13‡
Free fatty acids, mmol/l	0.81 ± 0.06	0.94 ± 0.09	1.07 ± 0.08	0.82 ± 0.09	0.93 ± 0.03
Total cholesterol, mmol/l	2.13 ± 0.12	1.80 ± 0.06‡	0.71 ± 0.05‡	1.33 ± 0.04‡	0.97 ± 0.04‡
HDL cholesterol, mmol/l	2.13 ± 0.06	1.70 ± 0.07‡	0.57 ± 0.05‡	1.32 ± 0.04‡	1.05 ± 0.04‡
Liver
Triglycerides, µmol/g	990.11 ± 37.73	1,324.50 ± 119.98*	1,280.56 ± 89.90	1,058.96 ± 73.03	994.93 ± 143.46
Free fatty acids, µmol/g	222.63 ± 39.49	202.18 ± 26.80	286.68 ± 29.12	318.29 ± 31.14	203.59 ± 31.52
Cholesterol, µmol/g	54.93 ± 2.65	109.58 ± 14.45†	103.03 ± 13.24†	77.74 ± 5.20	83.31 ± 10.22

Values are means ± SE (n = 6–8). Total triglycerides, free fatty acids, cholesterol, and HDL cholesterol were measured in mouse serum, and total triglycerides, free fatty acids, and cholesterol were measured in hepatic lipid extracts.

^*P < 0.05,

^†P < 0.01,

^‡P < 0.001, comparison of pregnant groups [days (D) 7–18] vs. nonpregnant group (D0). P values were determined by one-way ANOVA with Newman-Keuls post hoc testing.