FIG. 4.

Glioblastoma exosomes enhance therapeutic angiogenesis with FGF-2 in hind limb ischemia. (A) Glioblastoma exosomes were encapsulated in alginate beads. (B) Ischemia was induced in mice through femoral artery ligation, and the alginate beads were implanted at the time of surgery. (C) Laser speckle contrast imaging of blood perfusion in the feet of the mice over time. Mice were given alginate beads with either FGF-2 or FGF-2 with glioblastoma exosomes. (D) Analysis of perfusion of the feet after induction of hind limb ischemia. Relative blood flow was defined as the ratio between the ischemic limb and the control limb. *Statistically significant difference between FGF-2 with exosomes and alginate or FGF-2 groups (p < 0.05). ^†Statistically significant difference between exosome treatment group and alginate or FGF-2 treatment groups (p < 0.05). Color images available online at www.liebertpub.com/tea