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RSA (IC50) of 8HQ and its derivatives (1–9).
| Compound | IC50 (μM) |
|---|---|
| 8HQ (1) | 614.77 |
| NQ (2) | –a |
| Cloxyquin (3) | 1050.67 |
| 7-Br-8HQ (4) | 597.46 |
| 5,7-dichloro-8HQ (5) | 335.90 |
| CQ (6) | 366.02 |
| 5,7-diiodo-8HQ (7) | –a |
| 5-amino-8HQ (8) | 8.71 |
| 2-CN-8HQ (9) | –a |
| α-tocopherolb | 13.47 |
Compounds that exhibited <50% inhibition at 300 μg/mL were denoted as inactive antioxidants.
α-tocopherol was used as the positive control.
