Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Cytotoxicity (IC50) of compound 1-9 against MRC-5 cell line.
| Compound | IC50 (µM) |
|---|---|
| 8HQ (1)a | 6.27±0.58 |
| NQ (2) | 88.14±2.11 |
| Cloxyquin (3) | 81.74±0.96 |
| 7-Br-8HQ (4) | 22.09±1.30 |
| 5,7-dichloro-8HQ (5) | 27.98±0.87 |
| CQ (6) | 76.17±0.23 |
| 5,7-diiodo-8HQ (7) | –b |
| 5-amino-8HQ (8) | 22.14±1.02 |
| 2-CN-8HQ (9) | –b |
| Doxorubicinc | 0.62±0.03 |
See reference [12].
Compounds that exhibited <50% inhibition of cell growth at 50 µg/mL were denoted as non-cytotoxic.
Doxorubicin was used as the positive control.
