Table 2.

Alterations in ECM constituents

Acc.	Gene names	MP significant	Tumor versus normal		High versus low		Low versus normal		SC (Isella et al. 2015)
			log2FC	p value	log2FC	p value	log2FC	p alue
P27658	COL8A1	+	2.186	0.019	− 1.392	0.330	2.882	0.021	1.000
Q12884	FAP	+a	2.162	0.035	− 3.840	0.031	4.083	0.002	0.896
Q99715	COL12A1	+	2.100	0.002	− 1.027	0.266	2.614	0.003	0.994
Q13751	LAMB3	+	2.091	0.000	0.691	0.226	1.745	0.010	0.003
Q9Y4K0	LOXL2	+	1.809	0.003	− 1.260	0.218	2.439	0.001	0.975
A8TX70	COL6A5	+	− 1.778	0.007	0.800	0.312	− 2.178	0.007	0.981
Q05707	COL14A1	+	− 1.730	0.001	0.813	0.215	− 2.137	0.000	0.996
P55268	LAMB2	+	− 1.798	0.003	− 0.358	0.662	− 1.619	0.044	0.145
Q2UY09	COL28A1	+	− 2.288	0.006	0.377	0.701	− 2.476	0.026	0.396
Q07507	DPT	+	− 2.477	0.000	0.762	0.095	− 2.858	0.000	0.908
P07585	DCN	+	− 2.754	0.000	0.795	0.334	− 3.151	0.000	0.823
Q9BXN1	ASPN	+	− 2.929	0.001	− 0.857	0.571	− 2.501	0.020	0.994

The table shows proteins that are ECM constituents or involved in extra cellular matrix modulation. Negative values indicate higher abundance in normal, positive values higher in tumor samples. Normal, normal adjacent mucosa; tumor, tumor tissue; High, high stage tumor samples; low, low stage tumor samples; SC, stromal contribution. Stromal contribution reprinted by permission from Macmillian Publishers Ltd: Nature Genetics (47: 312–319), copyright (2015)

^aOnly low-stage versus normal is MP significant