Table 1.
| Reference and important notes | Sample Size | Findings in Overweight | Findings in Obese | Trend per increase in BMI |
|---|---|---|---|---|
| Protani et al. [2] | Meta-analysis of 14 studies | N/a | Poorer survival in obese (pooled HR 1.17; 95% CI 1.03–1.34) | N/a |
| Olsen et al. [3] | Meta-analysis of 28 studies | Increased EOC incidence: Pooled Effect Estimate 1.16 (1.01–1.32) | Increased EOC incidence: Pooled Effect Estimate 1.30 (1.12–1.50) | N/a |
| Reeves et al. [13] “Million Women Study” prospective cohort out of UK *BMI based on self reported ht and wt |
1.2 million in cohort 2406 EOC cases observed 1651 EOC deaths observed |
Increased EOC Incidence: FAR 1.13 (1.02–1.25) BMI 27.5–29.5 (n=349) vs. 22.5–24.9 (n=631) No Evidence of association in mildly overweight (BMI 25–27.4) Mortality: No evidence for correlation |
Increased EOC Incidence: FAR 1.12 (1.02–1.23) BMI ≥30 (n=438) vs. 22.5–24.9 (n=631) Poorer survival and increased mortality: FAR 1.16 (1.04–1.30) (n=326) |
Incidence: FAR 1.14 (1.03–1.27) for every 10 unit increase in BMI Mortality: FAR 1.17 (1.03–1.33) for every 10 unit increase in BMI |
| Engeland et al. [16] *BMI based on measured ht and wt |
1.1 million in cohort 7720 EOC cases observed | No evidence of association between overweight and EOC incidence | Increased incidence of EOC if BMI high (75th–84th %tile): RR 1.43 (1.00–2.04) or very high (≥ 85th %tile) RR 1.56 (1.04–2.32) in adolescence Increased risk for EOC if BMI ≥30.0 in twenties. RR 1.45 (1.02–2.04) No evidence of association between adult obesity and EOC |
N/a |
| Anderson et al. [14] “Iowa Women’s Health Study” Prospective cohort of women 55–69 followed for 15 years in Iowa, USA *BMI based on reported Ht and Wt *Reference group included underweight women (BMI <18.5) |
41,836 in cohort 223 EOC cases observed | No association with EOC incidence demonstrated | Increased EOC incidence RR 2.15 (1.05–4.40) BMI ≥ 30 vs. BMI <25 at age 18 Current BMI not associated with EOC risk | Linear dose response not found |
| Nagle et al. [20] | Meta-analysis of 21 studies with 12390 EOC cases | No significant association with OS demonstrated | OS disadvantage for women with BMI 30–34.9, pHR 1.10 (0.99–1.23) | Decreased OS pHR 1.03 (1.00–1.06) for every 5 unit increase in BMI |
| Liu et al. [19] | Meta-analysis of 26 studies with 12963 EOC cases | Increased risk for EOC, RR 1.07 (1.02–1.12) | Increased risk for EOC, RR 1.28 (1.16–1.41) | N/a |
FAR=floating absolute risk; RR=relative risk.