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. 2016 May 27;1(1):30–46. doi: 10.1002/btm2.10004

Figure 5.

Figure 5

Examples of targeting strategies using proteins. (a, b) Lactoferrin (Lf)‐functionalized iron oxide nanoparticles for delivery across the BBB. (a) Schematic of Lf‐coated iron oxide nanoparticles demonstrating the interactions between the nanoparticles and brain endothelial cells. (b) In vivo MRI image showing brain uptake of Lf‐coated iron oxide nanoparticles. Red dotted lines encircle areas of contrast where nanoparticles are present. (c, d) HDL nanoparticles for delivery to atherosclerotic plaque. (c) Schematic (left) and transmission electron microscopy (TEM) image (right) of statin‐loaded recombinant HDL nanoparticles ([S]‐rHDL). TEM image shows [S]‐rHDL were 26 nm in diameter. (d) Fluorescent imaging shows colocalization between the [S]‐rHDL particles labeled with dye and macrophages (CD68) at sites of plaque in an aorta. Scale bars = 400 μm for main panel and 100 μm for inset. (a, b) Adapted with permission from ref. 135. Copyright 2012 by American Chemical Society. (c, d) Adapted with permission from ref. 147. Copyright 2014 by Macmillan Publishers Ltd.