Table 2b. A list of patients who experienced recurrence of IDH mutant gliomas.
| b. IDH mutant gliomas with TP53 mutation | |||||||
| Case | Age, sex | WHO | Location | Recurrent pattern | sPFS (mo) | OS (mo) | F/U (mo) |
| TP53 mutation | CNAs | ||||||
| M1-1 | 48F | A Gr3 | Lt frontal | - | 177 | (alive) | 183 |
| R175H (exon 5) | +1pter-34.2, +2q36-ter, +7, +9q34.1-ter, −13q14.3-21.3, +16pter-12, +19qcen-13.3, −21q | ||||||
| M1-2 | 63F | GBM | Lt frontal | 1 | |||
| +1p, +1q, −2q24.3-31, +2q33-ter, +3pter-23, −4q21.3-ter, +4qcen-13.1, +7, −9p, +9q21.2-21.3, −10q, −13q14.1-22, +17p13-cen, +17qcen-21.2, +18p11.2-cen, +18qcen-21.1, −18q22-ter, −19q, −21q, | |||||||
| M1-3 | 63F | GBM | Rt parietal | 4 | |||
| +1q, −2q24.3-32.1, +3p, +4qcen-13.1, −4q21.1-ter, +7, −9p, −11q, −13q14.2-22, −17q25-ter, −18q21.3-ter, −19q, −21q, −22q | |||||||
| M2-1 | 22F | A Gr2 | Rt insula | - | 72 | (alive) | 115 |
| H193Y (exon 6) | none | ||||||
| M2-2 | 28F | A Gr3 | Rt insula, temporal, frontal | 2 | |||
| −13q22, +18p, +19, −X | |||||||
| M3-1 | 46F | A Gr2 | Lt frontal | - | 26 | (alive) | 37 |
| R306* (exon 8) | +3p, −5p, +8 −11p, −13q12.1-21.3, +13q22-ter | ||||||
| M3-2 | 49F | A Gr3 | Lt frontal | 1 | |||
| +2p, −3q21-ter, +4pter-13.1, −4q21.1-ter, −7p, +7q, −8pter-23.1, −9p, −10q, −11p, −13qcen-22, +13q32-ter, −14q, −17q, −18q | |||||||
| M3-D | 50F | No OP | Ventricular dissemnaiton | 5 | |||
| M4-1 | 34M | A Gr3 | Lt frontal | NA | 10 | 14 | (dead) |
| IHC | |||||||
| M4-R | 35M | No OP | Rt frontal | 4 | |||
| M5-1 | 44F | A Gr2 | Rt frontal | - | 27 | 65 | (dead) |
| R273H (exon 8) | −3p22-21, +7q, +8q22-ter, +11q23.3-ter, +12p, −13q21-31, −19q | ||||||
| M5-2 | 46F | A Gr3 | Rt frontal | 1 | |||
| −4q28-ter, +7q, +8q23-ter, +12p, −Xq | |||||||
| M5-R | 47F | No OP | Lt frontal | 4 | |||
| M6-1 | 22F | A Gr2 | Lt frontal | - | 78 | (alive) | 108 |
| R248W (exon 7) | −11q22-23.1 | ||||||
| M6-2 | 29F | GBM | Lt frontal | 1 | |||
| −3pter-3q24, −5p, +7, −11p, −11q22-23.1, −13q, −19q, −22, −X | |||||||
| M7-1 | 22M | A Gr2 | Rt frontal | - | 20 | 36 | (dead) |
| IHC | NA | ||||||
| M7-2 | 23M | A Gr2 | Rt frontal, Lt frontal | 4 | |||
| +7q, +8q, −19q | |||||||
| M8-1 | 33M | A Gr2 | Rt frontal | - | 12 | (alive) | 100 |
| R273H (exon 8) | +8q22.3-ter, −12q13-24.1 | ||||||
| M8-2 | 34M | A Gr3 | Rt frontal | 1 | |||
| +4p, −4q, −5qcen-13, −5q21-ter, +8q13-ter, −9pter-21.3, −11p, +12p, −12q22-23 | |||||||
| M8-3 | 38M | HGG | Rt cerebellum | 4 | |||
| −5q31.1-ter, +8q22.3-ter, +10p, −10q, +12p | |||||||
| M8-R | 41M | No OP | midbrain | 4 | |||
| M8-R | 42M | No OP | Bi basal nucleus | 4 | |||
| M9-1 | 61F | A Gr2 | Rt frontal | - | 20 | (alive) | 74 |
| Y163C (exon 5) | +7q31-ter, −X | ||||||
| M9-2 | 64F | A Gr2 | Rt frontal | 1 | |||
| +7q31.1-ter, +12q22-ter, −X | |||||||
| M10-1 | 30F | A Gr2 | Rt frontal | - | 41 | (alive) | 67 |
| D281G (exon 8) | −6q, −9p, −14q22-ter, −19q | ||||||
| M10-2 | 35F | GBM | Rt frontal | 1 | |||
| −3p, −6q, −9p. −12p, −14q, −15q, +18, −19q | |||||||
| M11-1 | 41M | A Gr2 | Lt frontal | - | 47 | (alive) | 78 |
| R175H (exon 5) | +7q, +10q24-ter | ||||||
| M11-2 | 45M | A Gr2 | Lt frontal | 1 | |||
| −5p, +7q, −18q21.1-ter | |||||||
| M11-3 | 47M | A Gr3 | Lt frontal | 1 | |||
| −5p, +7q, −8pter-23.1, −9p, −10pter-13, +10q26.1, −11p, −13qcen-22, −21q21, −22q, −X | |||||||
| M12-1 | 26M | ND | Rt frontal | - | 18 | 67 | (dead) |
| Y236D (exon 7) | +7q, +8q22.1-ter, +11q23.3-ter, +12p, +19 | ||||||
| M12-2 | 30M | GBM | Rt frontal, lt frontal | 4 | |||
| −4q28-ter, +5pter-q23.3, +7q, +8q, −9p, −9q, −11pter-15.1, −11q23.1-ter, +12p, −13q21.1-22, +13q31-ter |
|||||||
| M12-3 | 31M | HGG | Rt frotanl , lt frontal | 4 | |||
| +7q, +8q, −9p, −X | |||||||
| M13-1 | 37F | A Gr2 | Lt insula | - | 29 | 102 | (dead) |
| Y220C (exon 6) | +7 | ||||||
| M13-2 | 44F | A Gr3 | Lt insula, frontal | 2 | |||
| +2p, −3p21.3-11.2, +7, +8q23-ter, +10pter-12.3, −19q13.2-ter | |||||||
| M13-3 | 45F | A Gr3 | Rt frontal | 4 | |||
| NA | |||||||
| M14-1 | 30M | A Gr2 | Lt frontal | - | 9 | (alive) | 19 |
| G287E (exon 8) | +7q, −9p, +10p, +19p | ||||||
| M14-2 | 31M | A Gr3 | Lt frontal | 1 | |||
| NA | |||||||
| M14-R | 32M | No OP | Rt frontal | 3 | |||
| M15-1 | 48M | A Gr3 | Lt frontal | - | 51 | 67 | (dead) |
| R175H (exon5) | −4q13-21, +7q, +13q31-ter, +X | ||||||
| M15-2 | 52M | A Gr3 | Lt frontal ∼ parietal | 2 | |||
| +2pter-22, +3pter-23, +4q21-24, +4q26-33, −6pter-22, −6q21-ter, +7q, −9pter-21, −12p13, +20q | |||||||
| M16-1 | 25M | A Gr2 | Lt parietal | - | 15 | 25 | (dead) |
| IHC | −4q22-ter, +5pter-23.3, −5q31.2-ter, +7, +8q, +13, −19q, −22 | ||||||
| M16-2 | 27M | GBM | Lt Parietal | 1 | |||
| −3q11.2-24, +3q24.1-ter, +4p, −4q, +5pter-5q23.3, −5q31.2-ter, −6pter-22.1, +6p22.2-18.3, −6q21-26, +7, +8q, −9p, +13, −14q, +16q, +17q, −18, −19q, +21, −22 | |||||||
| M16-RD | 27M | No OP | Lt parietal, temporal, cerebellum | 4 | |||
This table includes age at diagnosis, gender, histology, tumor location, radiological recurrence pattern, PFS, OS, follow-up time in months, location of the TP53 mutation (TP53 mutant tumors only), and CNAs obtained by metaphase CGH for 1p/19q co-deleted gliomas and TP53 mutant gliomas. The letters ‘R’ and ‘D’ indicate that remote recurrence and intraventricular dissemination were detected, respectively, although additional surgery was not performed. Abbreviation: CNA copy number aberration, PFS progression-free survival, OS overall survival, F/U follow-up, A diffuse or anaplastic astrocytoma, IDH-mutant, O (anaplastic) oligodendroglioma and 1p/19q-codeleted, IDH-mutant, HGG high-grade glioma, Gr grade, IHC immunohistochemistry