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. 2017 Jun 21;8(49):84986–84995. doi: 10.18632/oncotarget.18583

Figure 1. Simultaneous inhibition of BRD4 and CDK9 synergistically induces apoptosis in rhabdoid tumor cells in vitro and inhibits cell proliferation in vivo.

Figure 1

The indicated RT cell lines were treated with BRD4 and CDK9 inhibitors as single compounds or as a combination of both at different concentrations. Evaluation of apoptosis by flow cytometry shows a strong synergism on apoptosis induction after combined treatments with JQ1/LDC067 (A) or iBET/DRB (B). Rhabdoid tumor xenograft mice were treated with Vehicle, JQ1, LDC067 or simultaneously with JQ1 plus LDC067 during 3 weeks, followed by an observation period of three additional weeks. Tumor size was measured twice a week by digital caliper (C). Box-plots show the average tumor volume at the end of the experiment (D). *p<0.05, **p<0.01, ***p<0.001, ****p < 0.0001 (ANOVA One-way test).