Table 3. Association of Ano1 expression with Ki67 expression in breast cancer patients with different ER, PR, and HER2 status.
| Ki67 expression | Ano1 expression | |||
|---|---|---|---|---|
| Low n (%) |
High n (%) |
P value†,‡ | OR(95%CI)§ | |
| ER-positive patients | ||||
| Low | 97(39.9) | 146(60.1) | 0.054† | 1 (reference) |
| High | 20(57.1) | 15(42.9) | 0.048‡ | 0.480(0.232-0.995) |
| ER-negative patients | ||||
| Low | 48(43.6) | 62(56.4) | 0.467† | 1 (reference) |
| High | 10(52.6) | 9(47.4) | 0.480‡ | 0.699(0.259-1.885) |
| PR-positive patients | ||||
| Low | 94(39.2) | 146(60.8) | 0.289† | 1 (reference) |
| High | 17(48.6) | 18(51.4) | 0.250‡ | 0.654(0.317-1.348) |
| PR-negative patients | ||||
| Low | 51(45.1) | 62(54.9) | 0.060† | 1 (reference) |
| High | 13(68.4) | 6(31.6) | 0.057‡ | 0.356(0.123-1.029) |
| HER2-postive patients | ||||
| Low | 25(29.8) | 59(70.2) | 0.801† | 1 (reference) |
| High | 4(33.3) | 8(66.7) | 0.935‡ | 0.942(0.227-3.911) |
| HER2-negative patients | ||||
| Low | 120(44.6) | 149(55.4) | 0.037† | 1 (reference) |
| High | 26(61.9) | 16(38.1) | 0.040‡ | 0.497(0.255-0.969) |
Abbreviations: ER, Estrogen receptor; PR, Progesterone receptor; HER2, Human epidermal growth factor receptor.
† P values were calculated from 2-sided chi-square tests or Fisher’s Exact Test.
‡P values were calculated by unconditional logistic regression adjusted for age, menopause state.
§OR and 95% CI values were calculated by unconditional logistic regression adjusted for age, menopause status, first degree family history of breast cancer.