Table 4. Differences in Dietary Inflammatory Index (DII) according to histopathological types among the gastric cancer patients (n=301).
| All types (n=301) | Intestinal type (n=146) | Diffuse type (n=155) | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| No. of Controls, n (%) | No. of Cases, n (%) | Crude OR (95% CI) | Multi- variable OR (95% CI) | p for int. | No. of Cases, n (%) | Crude OR (95% CI) | Multi- variable OR (95% CI) | p for int. | No. of Cases, n (%) | Crude OR (95% CI) | Multi-variable OR (95% CI) | p for int. | |
| Total | 776 (72.05) |
301 (27.95) |
146 (48.50) |
155 (51.50) | |||||||||
| T1 | 258 (33.25) | 71 (23.59) |
1.0 (ref) | 1.0 (ref) | 29 (19.86) | 1.0 (ref) | 1.0 (ref) | 42 (27.10) | 1.0 (ref) | 1.0 (ref) | |||
| T2 | 259 (33.38) | 85 (28.24) | 1.19 (0.83, 1.71) |
1.42 (0.95, 2.12) |
41 (28.08) | 1.41 (0.85, 2.34) |
1.86 (1.04, 3.32) |
44 (28.39) | 1.04 (0.66, 1.65) |
1.14 (0.70, 1.86) |
|||
| T3 | 259 (33.38) | 145 (48.17) | 2.03 (1.46, 2.84) |
1.86 (1.28, 2.70) |
76 (52.05) | 2.61 (1.65, 4.14) |
2.33 (1.37 3.96) |
69 (44.52) |
1.64 (1.08, 2.49) |
1.49 (0.95, 2.35) |
|||
|
p-value for trend |
<0.001 | 0.001 | <0.001 | 0.002 | 0.017 | 0.077 | |||||||
| Sex | |||||||||||||
| Men | 498 (72.07) | 193 (27.93) | 0.029 | 122 (83.56) |
0.142 | 71 (45.81) | |||||||
| T1 | 144 (28.92) | 44 (22.80) | 1.0 (ref) | 1.0 (ref) | 23 (18.85) |
1.0 (ref) | 1.0 (ref) | 21 (29.58) | 1.0 (ref) | 1.0 (ref) | |||
| T2 | 156 (31.33) |
52 (26.94) | 1.09 (0.69, 1.73) |
1.40 (0.82, 2.38) |
37 (30.33) | 1.49 (0.84, 2.62) |
2.19 (1.12, 4.28) |
15 (21.13) | 0.66 (0.33, 1.33) |
0.76 (0.36, 1.60) |
0.037 | ||
| T3 | 198 (39.76) | 97 (50.26) | 1.60 (1.06, 2.43) |
1.55 (0.95, 2.52) |
62 (50.82) | 1.96 (1.16, 3.31) |
2.03 (1.09, 3.77) |
35 (49.30) | 1.21 (0.68, 2.17) |
1.09 (0.57, 2.05) |
|||
|
p-value for trend |
0.017 | 0.086 | 0.011 | 0.046 | 0.399 | 0.724 | |||||||
| Women | 278 (72.02) | 108 (27.98) | 24 (16.44) | 84 (54.19) | |||||||||
| T1 | 114 (41.01) | 27 (25.00) | 1.0 (ref) | 1.0 (ref) | 6 (25.00) | 1.0 (ref) | 1.0 (ref) | 21 (25.00) | 1.0 (ref) | 1.0 (ref) | |||
| T2 | 103 (37.05) |
33 (30.56) | 1.35 (0.76, 2.40) |
1.41 (0.75, 2.67) |
4 (16.67) | 0.74 (0.20, 2.69) |
0.67 (0.16, 2.77) |
29 (34.52) | 1.53 (0.82, 2.85) |
1.61 (0.81, 3.21) |
|||
| T3 | 61 (21.94) | 48 (44.04) | 3.32 (1.89, 5.84) |
3.25 (1.75, 6.05) |
14 (58.33) | 4.36 (1.60, 11.92) |
4.87 (1.47, 16.07) |
34 (40.48) | 3.03 (1.62, 5.66) |
2.93 (1.47, 5.84) |
|||
|
p-value for trend |
<0.001 | <0.001 | 0.003 | 0.008 | 0.001 | 0.002 | |||||||
|
H. pylori infection |
|||||||||||||
| Positive | 478 (63.65) | 273 (36.35) | 0.126 | 129 (88.36) |
0.438 | 144 (92.90) | |||||||
| T1 | 158 (33.05) | 66 (24.18) | 1.0 (ref) | 1.0 (ref) | 26 (20.16) | 1.0 (ref) | 1.0 (ref) | 40 (27.78) | 1.0 (ref) | 1.0 (ref) | |||
| T2 | 150 (31.38) | 78 (28.57) | 1.25 (0.84, 1.85) |
1.45 (0.95, 2.23) |
36 (27.91) | 1.46 (0.84, 2.53) |
1.85 (0.98, 3.51) |
42 (29.17) | 1.11 (0.68, 1.80) |
1.19 (0.71, 1.98) |
0.164 | ||
| T3 | 170 (35.56) | 129 (47.25) | 1.82 (1.26, 2.62) |
1.69 (1.13, 2.51) |
67 (51.94) | 2.40 (1.45, 3.96) |
2.16 (1.21, 3.87) |
62 (43.06) | 1.44 (0.92, 2.27) |
1.37 (0.85, 2.21) |
|||
|
p-value for trend |
0.001 | 0.012 | <0.001 | 0.012 | 0.106 | 0.196 | |||||||
| Negative | 298 (91.41) | 28 (8.59) |
17 (11.64) |
11 (7.10) | |||||||||
| T1 | 100 (33.56) |
5 (17.86) |
1.0 (ref) | 1.0 (ref) | 3 (17.65) |
1.0 (ref) | 1.0 (ref) | 2 (18.18) | 1.0 (ref) | 1.0 (ref) | |||
| T2 | 109 (36.58) |
7 (25.00) | 1.28 (0.40, 4.18) |
1.32 (0.38, 4.62) |
5 (29.41) | 1.53 (0.36, 6.56) |
1.85 (0.39, 8.77) |
2 (18.18) | 0.92 (0.13, 6.64) |
0.82 (0.10, 6.62) |
|||
| T3 | 89 (29.87) | 16 (57.14) | 3.60 (1.27, 10.21) |
3.50 (1.14, 10.75) |
9 (52.94) |
3.37 (0.89, 12.84) |
3.61 (0.86, 15.19) |
7 (63.64) | 3.93 (0.80, 19.42) |
3.66 (0.66, 20.39) |
|||
|
p-value for trend |
0.009 | 0.016 | 0.057 | 0.065 | 0.057 | 0.076 | |||||||
Adjusted for total caloric intake, body mass index, education, smoking (pack year), ethanol amount, physical activity, H. pylori infection, and first-degree family history of gastric cancer; The tertile ranges of DII were categorized based on the distribution of the control group (T1: <0.96, T2: 0.96-2.97, T3: ≥2.97); p for int.: p-value for interaction.