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(A-C) Local invasion stage (T1, T2, T3, T4), lymph node metastasis (N0, N1, N2), distant metastasis (M0, M1); overall log-rank test, p-value <0.0001. (D) TNM stage, overall log-rank test, p-value <0.0001. The differences between the two curves were determined by the two-sided log-rank test.
