Table 3. Univariate and multivariate analyses of prognostic factors and overall survival of patients in the study.
Variables | Categories | Univariate analysis | Multivariate analysis | ||
---|---|---|---|---|---|
HR (95% CI) | P value | HR (95% CI) | P value | ||
Training set, n=498 | |||||
Age | ≧60/<60years | 1.263 (0.767-2.081) | 0.358 | ||
Sex | male/female | 1.177 (0.767-2.081) | 0.465 | ||
Local invasion | T3-T4/T1-T2 | 3.798 (1.752-13.14) | 0.013 | 2.206 (1.139-7.029) | 0.027 |
Lymph node metastasis | N0/N1-N2 | 3.207 (2.026-5.075) | <0.0001 | 1.172 (0.672-2.044) | 0.576 |
Distant metastasis | M0/M1 | 3.289 (3.397-7.235) | <0.0001 | 2.464 (1.363-4.453) | 0.003 |
TNM stage | I-II/III-IV | 4.348 (2.661-7.104) | <0.0001 | 2.151 (1.165-3.971) | 0.014 |
Risk score(RS) | High/low | 5.641 (3.441-9.245) | <0.0001 | 4.463 (2.687-7.413) | <0.0001 |
Testing set, n=100 | |||||
Age | ≧60/<60years | 1.126 (0.972-1.305) | 0.112 | ||
Sex | male/female | 0.948 (0.864-1.041) | 0.271 | ||
Local invasion | T3-T4/T1-T2 | 2.008 (1.129-3.571) | 0.017 | 1.503 (0.8583-2.634) | 0.153 |
Lymph node metastasis | N0/N1-N2 | 2.729 (1.655-4.501) | 0.0001 | 2.928 (0.197-3.933) | 0.478 |
Distant metastasis | M0/M1 | 2.383 (1.906-2.978) | <0.0001 | 2.951 (1.122-7.759) | 0.028 |
TNM stage | I-II/III-IV | 3.177 (1.995-5.061) | <0.0001 | 3.548 (1.037-12.13) | 0.009 |
Risk score(RS) | High/low | 2.542 (1.671-3.879) | <0.0001 | 2.206 (1.139-7.029) | 0.004 |
Independent set, n=65 | |||||
Age | ≧60/<60years | 1.247 (0.446-2.318) | 0.612 | ||
Sex | male/female | 1.642 (0.845–3.120) | 0.385 | ||
Local invasion | T3-T4/T1-T2 | 1.677 (0.394-7.141) | 0.483 | ||
Lymph node metastasis | N0/N1-N2 | 2.969(1.123-7.845) | 0.028 | 2.281 (1.189-3.784) | 0.021 |
Distant metastasis | M0/M1 | 3.289 (3.397-7.235) | <0.0001 | 2.367 (1.394-4.019) | 0.001 |
TNM stage | I-II/III-IV | 5.008 (2.242-11.410) | <0.0001 | 2.138 (1.047-3.841) | 0.025 |
Risk score(RS) | High/low | 5.025 (2.259–11.643) | 0.0002 | 4.247 (2.132-8.463) | <0.0001 |
HR, hazard ratio; CI, confidential interval.