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. 2017 Aug 12;8(49):85516–85525. doi: 10.18632/oncotarget.20231

Figure 5. Tumor histology in untreated and TEM and rMETase-treated BRAF-V600E mutant melanoma PDOX models.

Figure 5

(A) Untreated control was comprised of viable cells without obvious necrosis. Epithelioid melanoma cells, devoid of melanin, with a high mitotic index are present. (B) Tumor treated with TEM showed partial necrosis. (C) Tumor treated with rMETase. Mitotic figures are present, indicating rMETase did not completely arrest the cell cycle. Tumor treated with rMETase showed partial necrosis similar to TEM. (D) Tumor treated with the combination of TEM and rMETase showed extensive necrosis. White allows: necrotic areas. Scale bars: 50 μm.